Induction of Oral Tolerance in Mice by Continuous Feeding with β-Lactoglobulin and Milk
نویسندگان
چکیده
منابع مشابه
Induction of oral tolerance in mice by continuous feeding with beta-lactoglobulin and milk.
We examined the immune response of mice to beta-lactoglobulin (BLG), a potent milk allergen, after continuous feeding of a BLG solution or milk instead of drinking-water. Strong suppression of the anti-BLG antibody response and antigen-specific T cell response were observed in mice fed BLG and milk. Although the profile of the antibody specificity to BLG peptides in mice fed BLG or milk was dif...
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Methods BALB/cJ mice were gavaged with PBS (control mice) or with 2 mg of purified BLG on days 1, 2, 3, 8, 9 and 10. All mice were then sensitized by i.p. administration of 5 μg of BLG in alum on day 14. Mice sensitization was assessed by quantitative measurement of BLG-specific IgE and IgG1 antibodies on individual serum samples collected on day 36. After a boost administration of BLG/alum, el...
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Various opinions have been presented on the merits and demerits that breastfeeding gives for the allergic onset of the babies. In this report, we focused on whether food proteins eaten by mother mice and secreted into breast milk as IgA-immune complexes contribute to the allergy prevention through oral tolerance in infants who ingest the milk. BALB/c mice were divided into two groups; E-group f...
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ژورنال
عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry
سال: 2002
ISSN: 0916-8451,1347-6947
DOI: 10.1271/bbb.66.1287